Multi Column Select is a simple plugin that will hide the select control and then display a multicolumn dropdown (css). Uses the original form control so will work if JS is not enabled and the form can be processed as normal.
gentleSelect is a jQuery plugin for transforming select boxes into a skinnable alternative. The selection list can be rendered with multiple columns/rows to present larger datasets in a more manageable format. It recognizes the multiple attribute on select boxes and does the right thing automatically.
Columnizer jQuery plugin will automatically layout your content in newspaper column format. You can specify either column width or a static number of columns.
Nested is a jQuery plugin to create a gap free, multi column grid layouts. Nested plugin also sports a responsive design.
jQuery SooperFish is a mobile & touchscreen friendly drop down menu script. The script supports multi-column sub menus by automatically dividing menus into 2 or 3 columns when the number of items in a sub menu exceeds a configurable limit.
Gridster is a jQuery plugin that allows building intuitive draggable layouts from elements spanning multiple columns. You can even dynamically add and remove elements from the grid. It is on par with sliced bread, or possibly better.